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Peanut Oral Immunotherapy Using Store-Bought, Home-Measured Products is Effective for Children with High-Threshold Peanut Allergy


News provided by

The American Academy of Allergy, Asthma & Immunology

Feb 15, 2025, 09:00 ET

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AAAAI
AAAAI

In this study, 100% of participants in the peanut oral immunotherapy group tolerated 9,043 mg of peanut product after treatment

MILWAUKEE, Feb. 15, 2025 /PRNewswire-PRWeb/ -- For children with high threshold peanut allergy, oral immunotherapy using store-bought and home-measured peanut products provided significantly higher rates of desensitization compared to peanut avoiders, according to new research being presented at the 2025 AAAAI / WAO Joint Congress.

"Studies for treatment of peanut allergy, such as omalizumab and oral, sublingual or epicutaneous immunotherapy have typically focused on those with a low threshold of reaction, less than one peanut. Our study uniquely addressed those with a higher threshold, representing about half of those with a peanut allergy and conveniently used store-bought, home-measured peanut. We were excited to see incredibly high success rates of participants tolerating a serving size of peanut, even after a period without daily dosing. The approach was safe and very inexpensive and could be applied to select patients with careful allergist supervision," said lead author Scott H. Sicherer, MD, FAAAAI, of the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai in New York where the study was conducted.

"The research... showed 100% success for peanut desensitization in the oral immunotherapy group compared to only 21.0% for the peanut avoidance group"

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Approved peanut allergy therapeutics typically address patients with low allergen thresholds, but nearly half of people with peanut allergies have higher thresholds and may be easily treatable, according to research. In this phase 2 trial, participants ranging from age 4 to 14 years old, reacting to cumulative peanut doses of 443-5043 mg, were randomized into an avoidance group and a peanut oral immunotherapy (POIT) group to evaluate respondence to an approximately 3400 mg maintenance dose of store-purchased, home-measured peanut products. During the study, 73 participants fulfilled the entry criteria and 38 were randomized to the POIT. Afterwards, in an oral challenge (OFC), participants were given up to 9,043 mg of peanut protein. For those on POIT tolerating 9,043 mg, researchers undertook another OFC for sustained unresponsiveness (SU) that was determined after 16 weeks of ad-libitum ingestion before 8 weeks of peanut avoidance.

The research, funded by the NIAID, showed 100% success for peanut desensitization in the POIT group compared to only 21.0% for the peanut avoidance group. The results also found that 100% of the group treated with POIT tolerated 9,043 mg in the oral food challenge while only 10% of the avoidance group tolerated the same amount. Additionally, 86.7% of the POIT group continued to tolerate 9,043 mg on sustained unresponsiveness evaluation and by intention-to-treat, and 68.4% on POIT achieved sustained unresponsiveness/natural tolerance of 9,043 mg compared to 8.6% who continued avoiding.

Visit aaaai.org to learn more about peanut allergies. Research presented at the 2025 AAAAI / WAO Joint Congress, February 28 – March 3 in San Diego, CA, is published in an online supplement to The Journal of Allergy and Clinical Immunology (JACI).

The American Academy of Allergy, Asthma & Immunology (AAAAI) is the leading membership organization of more than 7,100 allergists, asthma specialists, clinical immunologists and other professionals with a special interest in the research and treatment of allergic and immunologic diseases. Established in 1943, the AAAAI is the go-to resource for patients living with allergies, asthma and immune deficiency disorders.

Media Contact

Candace Archie, The American Academy of Allergy, Asthma & Immunology, (414) 272-6071, [email protected], aaaai.org 

SOURCE The American Academy of Allergy, Asthma & Immunology

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